If you are using native MPIO you shouldn't need to uninstall and reinstall. However if you are not using using the EVA to 3par online migration tool, your UUIDs are going to change when the storage is presented in 3par. EVA uses a different scheme than 3PAR so your paths in MPIO are going to change. Using the EVA - 3PAR online migration tool keeps the same UUIDs so this process can be done completely online in unix. I would assume this is the same as it is in linux as the documentation states that host i/o is not stopped during this process like it is in windows. I don't have any experience using the MPX tool that you referenced.
We run RHEL6.4 using the native MPIO just fine with no issues. To view compatibility check the matrix in SPOCK
http://h20272.www2.hp.com and it should tell you all of the information you need to know about compatibility. You'll just need to login using a passport account.